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Links between three-dimensional patellar kinematics, cartilage morphology and varus/algus alignment in early knee osteoarthritis McWalter, Emily Jane
Abstract
In this pilot study, we assessed the relationship between three-dimensional patellar kinematics and patellofemoral cartilage morphology in 10 individuals with varus or valgus alignment and early knee osteoarthritis (OA). We used a novel, validated, non-invasive magnetic resonance imaging (MRI)-based technique to assess three-dimensional patellar kinematics and a validated quantitative MRI (qMRI) technique to assess cartilage morphology at the patellofemoral joint. Varus and valgus alignment was assessed from a standing anteriorposterior radiograph. Differences in three-dimensional patellar kinematics between the varus and valgus groups were assessed using a random effects model. We found that the varus group displayed constant medial tilt, constant external spin and decreasing anterior translation with increasing tibiofemoral flexion. We found that the valgus group displayed increasing medial tilt, constant internal spin, a greater proximal position and a constant anterior position with increasing tibiofemoral flexion. No difference was seen in lateral translation between the varus and valgus groups and the patella was centred in the trochlear groove. Medial and lateral compartment cartilage morphology was compared to varus and valgus alignment using a two-way analysis of variance (ANOVA). No difference was found between the varus and valgus groups. A power analysis revealed that 30 subjects are required in each group to detect a significant difference. The relationship between three-dimensional patellar kinematics and the ratio of medial to lateral compartment cartilage morphology was assessed using a regression model. We found that the rate of medial tilt increased with decreasing ratio of medial to lateral compartment bone/cartilage interface area. Results suggested a relationship between lateral patellar translation and proportion of medial to lateral cartilage normalized volume, mean thickness and percentage cartilage coverage. This finding was greatly influenced by two data points and therefore this result is not conclusive. . Cartilage degeneration at the patellofemoral joint cannot be completely explained by the presence of varus or valgus malalignment. Other local biomechanical factors, such as kinematics, are likely involved. A better understanding of the relationship between threedimensional patellar kinematics and cartilage degeneration allows for the development of improved treatment strategies to arrest the onset and progression of patellofemoral OA.
Item Metadata
Title |
Links between three-dimensional patellar kinematics, cartilage morphology and varus/algus alignment in early knee osteoarthritis
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2004
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Description |
In this pilot study, we assessed the relationship between three-dimensional patellar
kinematics and patellofemoral cartilage morphology in 10 individuals with varus or valgus
alignment and early knee osteoarthritis (OA). We used a novel, validated, non-invasive
magnetic resonance imaging (MRI)-based technique to assess three-dimensional patellar
kinematics and a validated quantitative MRI (qMRI) technique to assess cartilage
morphology at the patellofemoral joint. Varus and valgus alignment was assessed from a
standing anteriorposterior radiograph.
Differences in three-dimensional patellar kinematics between the varus and valgus
groups were assessed using a random effects model. We found that the varus group
displayed constant medial tilt, constant external spin and decreasing anterior translation with
increasing tibiofemoral flexion. We found that the valgus group displayed increasing medial
tilt, constant internal spin, a greater proximal position and a constant anterior position with
increasing tibiofemoral flexion. No difference was seen in lateral translation between the
varus and valgus groups and the patella was centred in the trochlear groove.
Medial and lateral compartment cartilage morphology was compared to varus and
valgus alignment using a two-way analysis of variance (ANOVA). No difference was found
between the varus and valgus groups. A power analysis revealed that 30 subjects are
required in each group to detect a significant difference.
The relationship between three-dimensional patellar kinematics and the ratio of
medial to lateral compartment cartilage morphology was assessed using a regression model.
We found that the rate of medial tilt increased with decreasing ratio of medial to lateral
compartment bone/cartilage interface area. Results suggested a relationship between lateral
patellar translation and proportion of medial to lateral cartilage normalized volume, mean
thickness and percentage cartilage coverage. This finding was greatly influenced by two data
points and therefore this result is not conclusive. .
Cartilage degeneration at the patellofemoral joint cannot be completely explained by
the presence of varus or valgus malalignment. Other local biomechanical factors, such as
kinematics, are likely involved. A better understanding of the relationship between threedimensional
patellar kinematics and cartilage degeneration allows for the development of
improved treatment strategies to arrest the onset and progression of patellofemoral OA.
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Extent |
20585308 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-12-02
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0080789
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2005-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.