Go to  Advanced Search

Biochemical and mechanical effects of adrenergic and histaminergic drugs

Show full item record

Files in this item

Files Size Format Description   View
UBC_1975_A1 V47_5.pdf 6.503Mb Adobe Portable Document Format   View/Open
Title: Biochemical and mechanical effects of adrenergic and histaminergic drugs
Author: Verma, Subhash Chander
Degree: Doctor of Philosophy - PhD
Program: Pharmacology
Copyright Date: 1974
Issue Date: 2010-02-05
Series/Report no. UBC Retrospective Theses Digitization Project [http://www.library.ubc.ca/archives/retro_theses/]
Abstract: A time-response and dose-response study of the effects of norepinephrine and phenylephrine revealed that both agonists caused increases in cyclic AMP, cardiac contractility and phosphorylase a. in the isolated perfused guinea pig hearts. Norepinephrine caused a nearly five fold increase in cyclic AMP, whereas phenylephrine produced only a two-three fold increase in the nucleotide. Phenylephrine is less potent and less effective in elevating all the three parameters as compared to norepinephrine. Histamine and its analogs, TD and betazole increased cardiac contractility, phosphorylase a and levels of cyclic AMP in the isolated perfused guinea pig heart. The order of potency for the three compounds was histamine>TD>betazole. Cyclic AMP was found to increase prior to the increase in contractility or phosphorylase a. In the present study, the new H₂-receptor blocking agent burimamide, was found to be a specific, competitive blocking agent of both the mechanical and biochemical effects of histamine and its analogs on the heart. Burimamide did not affect the norepinephrine-induced increase in contractility, phosphorylase a or cyclic AMP. Promethazine did interact with cardiac histamine receptors, but the interaction was either non-competitive or competitive non-equilibrium in nature. [the rest of the abstract can be found in the attached PDF file]
Affiliation: Medicine, Faculty of
URI: http://hdl.handle.net/2429/19729
Scholarly Level: Graduate

This item appears in the following Collection(s)

Show full item record

UBC Library
1961 East Mall
Vancouver, B.C.
Canada V6T 1Z1
Tel: 604-822-6375
Fax: 604-822-3893