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Serotonin and exercise Walsh, Michael Leonard
Abstract
The effects of altering serotonin (5-HT) concentration on physical exercise were investigated in adult, male, hooded rats. The rats were trained to run on a treadmill at a speed of 40 m/min, then subjected to an exhaustive run. Serotonin levels were decreased by para-chlorophenylalanine (300 mg/kg; intragastric) and increased by 5-HT (50 ug; intraventricular). Rats with lowered 5-HT levels had a 30% increase in running time to exhaustion whereas their controls only had a 1% increase. Elevating 5-HT levels decreased running time 44% whereas appropiate controls had a 7% increase in running time. In some animals the effect of exercise on 5-HT levels in the cerebellum, medulla oblongata, hypothalamus, midbrain, striatum, hippocampus, and cortex were measured. When compared to yoked, shocked controls, exercised rats had no difference in the absolute levels of 5-HT except for a lesser amount in the hypothalamus. These results suggest that although exercise did not increase absolute 5-HT levels, changing resting levels of 5-HT can markedly alter subsequent running time to exhaustion.
Item Metadata
Title |
Serotonin and exercise
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1983
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Description |
The effects of altering serotonin (5-HT) concentration on physical exercise were investigated in adult, male, hooded rats. The rats were trained to run on a treadmill at a speed of 40 m/min, then subjected to an exhaustive run. Serotonin levels were decreased by para-chlorophenylalanine (300 mg/kg; intragastric) and increased by 5-HT (50 ug; intraventricular). Rats with lowered 5-HT levels had a 30% increase in running time to exhaustion whereas their controls only had a 1% increase. Elevating 5-HT levels decreased running time 44% whereas appropiate controls had a 7% increase in running time. In some animals the effect of exercise on 5-HT levels in the cerebellum, medulla oblongata, hypothalamus, midbrain, striatum, hippocampus, and cortex were measured. When compared to yoked, shocked controls, exercised rats had no difference in the absolute levels of 5-HT except for a lesser amount in the hypothalamus. These results suggest that although exercise did not increase absolute 5-HT levels, changing resting levels of 5-HT can markedly alter subsequent running time to exhaustion.
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Genre | |
Type | |
Language |
eng
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Date Available |
2010-04-23
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0077280
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.