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Viral interaction with molecular chaperones : role in regulating viral infection

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dc.contributor.author Luo, Honglin
dc.contributor.author Wong, Jerry
dc.contributor.author Xiao, Allen
dc.date.accessioned 2010-07-16T23:04:02Z
dc.date.available 2010-07-16T23:04:02Z
dc.date.issued 2010-07-04
dc.identifier.citation Xiao, A., Wong, J., Luo, H. Viral interaction with molecular chaperones: role in regulating viral infection. Arch Virol. 2010; 155:1021–1031. DOI: 10.1007/s00705-010-0691-3. The original publication is available at www.springerlink.com. en
dc.identifier.uri http://hdl.handle.net/2429/26567
dc.description.abstract As essential effectors in protein quality control, molecular chaperones serve as the primary checkpoint to assist proper protein folding, and prevent misfolded proteins from denaturation and aggregation. In addition, chaperones can function to direct terminally-misfolded proteins to the proteolytic system for degradation. Viruses rely on host cell machineries for productive infection. Like for many other processes, various viruses have been shown to evolve mechanisms to utilize or subvert the host protein quality control machinery to support the completion of their life cycle. Furthermore, recent studies suggest that some viruses encode for their own chaperone-like proteins to enhance their infectivity. This review summarizes the current understanding of the interplay between molecular chaperones and viral proteins, highlights the chaperone activities of a number of viral proteins, and discusses potential anti-viral therapeutic strategies targeting the virus-chaperone interactions. [DOI: 10.1007/s00705-010-0691-3. The original publication is available at www.springerlink.com] en
dc.language.iso eng en
dc.publisher SpringerLink en
dc.relation.ispartof Canadian Institutes of Health Research (CIHR) Research Outputs 2010 en
dc.subject Protein assembly en
dc.subject Protein folding en
dc.subject Virus infection en
dc.subject Heat-shock protein en
dc.subject Chaperone en
dc.title Viral interaction with molecular chaperones : role in regulating viral infection en
dc.type Text en
dc.type.text Article en
dc.description.affiliation James Hogg iCAPTURE Centre en
dc.description.affiliation Medicine, Faculty of en
dc.description.affiliation Pathology and Laboratory Medicine, Department of en
dc.description.affiliation Other UBC en
dc.description.reviewstatus Reviewed en
dc.description.scholarlevel Researcher en

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