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The design and synthetic studies of N ∝-[1-(carboxy)-9,11,21-(trioxo)-heneicosyl]-l-aspartyl-l-lysyl-(tert-butyl)-l-asparaginate, a tripeptide analogue of ionomycin Putland, Michael Stuart

Abstract

Ionomycin is a stereochemically complex calcium ionophore. An analogue (34) of ionomycin has been designed and its synthesis initiated. Regions of the analogue which parallel portions of ionomycin do not incorporate any of the chiral centers found in the natural product. The analogue 34 also incorporates a highly conserved tripeptide found in the calcium binding site of troponin C proteins. [ Formula omitted ]

Item Metadata

Title
The design and synthetic studies of N ∝-[1-(carboxy)-9,11,21-(trioxo)-heneicosyl]-l-aspartyl-l-lysyl-(tert-butyl)-l-asparaginate, a tripeptide analogue of ionomycin
Creator
Putland, Michael Stuart
Publisher
University of British Columbia
Date Issued
1990
Description
Ionomycin is a stereochemically complex calcium ionophore. An analogue (34) of ionomycin has been designed and its synthesis initiated. Regions of the analogue which parallel portions of ionomycin do not incorporate any of the chiral centers found in the natural product. The analogue 34 also incorporates a highly conserved tripeptide found in the calcium binding site of troponin C proteins. [ Formula omitted ]
Genre
Thesis/Dissertation
Type
Text
Language
eng
Date Available
2010-11-02
Provider
Vancouver : University of British Columbia Library
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
DOI
10.14288/1.0059767
URI
http://hdl.handle.net/2429/29761
Degree
Master of Science - MSc
Program
Chemistry
Affiliation
Science, Faculty of; Chemistry, Department of
Degree Grantor
University of British Columbia
Campus
UBCV
Scholarly Level
Graduate
Aggregated Source Repository
DSpace

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For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.