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The role of endogenous retinoic acid in jaw development

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Title: The role of endogenous retinoic acid in jaw development
Author: Fan, Churmy Yong
Degree Master of Science - MSc
Program Cell and Developmental Biology
Copyright Date: 2011
Publicly Available in cIRcle 2011-09-19
Abstract: The aim of this thesis is to study the effects of reducing retinoic acid (RA) levels in the embryonic face on jaw morphogenesis. One member of the Cytochrome P26 class of enzymes, CYP26A1, which degrades retinol products, was locally overexpressed in chicken embryos. I hypothesized that lowering RA levels would either affect jaw patterning, cell survival and/or cytodifferentiation. Chicken embryos at stage 15 and 20 (E2.5, 3.5) were injected with RCAS
URI: http://hdl.handle.net/2429/37477
Scholarly Level: Graduate

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