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The effect of diabetes mellitus on nervous tissue Rivers, William Alexander
Abstract
A group of alloxanized rats fed on a high salt diet were studied histologically to determine the direct or indirect effect of diabetes mellitus on the nervous system. The most significant changes observed were in the vascular system of the brain. Lesions of the arteries were identical with those found in arteriosclerosis and massive hemorrhages accompanied by multiple diffuse diapedesis not only in the arteries but also in the veins was indicative of hypertension. It is believed the hypertensive condition was induced by a combination of the diabetes and salt feeding. Associated with the vascular dysfunction generalized cerebral changes were noted. They included neuron degeneration, exhibited by loss of Nissl granules, vacuolization of the cytoplasm and cerebral softening. Also Gitter cell invasion and proliferation occurred at the sites of vascular disturbance. It appears that the neurological involvement in diabetes is a direct result of changes in the blood system and not of the disease itself.
Item Metadata
Title |
The effect of diabetes mellitus on nervous tissue
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1951
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Description |
A group of alloxanized rats fed on a high salt diet were studied histologically to determine the direct or indirect effect of diabetes mellitus on the nervous system. The most significant changes observed were in the vascular system of the brain. Lesions of the arteries were identical with those found in arteriosclerosis and massive hemorrhages accompanied by multiple diffuse diapedesis not only in the arteries but also in the veins was indicative of hypertension. It is believed the hypertensive condition was induced by a combination of the diabetes and salt feeding. Associated with the vascular dysfunction generalized cerebral changes were noted. They included neuron degeneration, exhibited by loss of Nissl granules, vacuolization of the cytoplasm and cerebral softening. Also Gitter cell invasion and proliferation occurred at the sites of vascular disturbance. It appears that the neurological involvement in diabetes is a direct result of changes in the blood system and not of the disease itself.
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Genre | |
Type | |
Language |
eng
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Date Available |
2012-03-19
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0106898
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.