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A synthetic approach to quinocarcin and cyanocycline A : the Ugi reaction of complex aminoacids

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Title: A synthetic approach to quinocarcin and cyanocycline A : the Ugi reaction of complex aminoacids
Author: Turner, Charles Dylan
Degree Doctor of Philosophy - PhD
Program Chemistry
Copyright Date: 2012
Publicly Available in cIRcle 2012-08-08
Abstract: This dissertation describes synthetic efforts towards the natural products quinocarcin and cyanocycline A. Our approach capitalizes on the Ugi reaction of a complex pyroglutamol-derived aminoacid. This ambitious strategy first required the synthesis of the aminoacid, which required considerable development; ultimately the route was optimized to become practical and consistently high-yielding. Ugi condensation reactions using this material were successful, providing advanced precursors of the target molecules.
URI: http://hdl.handle.net/2429/42880
Scholarly Level: Graduate

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