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Towards intra-operative dosimetry for prostate brachytherapy : improved seed detection and registration to ultrasound using needle detection

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dc.contributor.author Lobo, Julio
dc.date.accessioned 2012-10-23T13:57:50Z
dc.date.available 2013-04-30
dc.date.copyright 2012 en_US
dc.date.issued 2012-10-23
dc.identifier.uri http://hdl.handle.net/2429/43524
dc.description.abstract Errors in seed placement during low dose rate prostate brachytherapy can result in over-treating healthy tissue and/or under-treating cancer cells. In a standard treatment procedure, seeds are implanted according to a planned seed distribution. This pre-operative plan (pre-plan) is created using an ultrasound volume scan taken about two weeks earlier. Errors in seed placement can occur due to changes in prostate structure during those two weeks, and from seed displacement during and after the actual operation. This thesis presents methods of seed localization that are suitable for both postoperative and intra-operative use. The techniques can be applied to the imaging modalities used in the current operation setup to implement a method of intraoperative planning. This involves using Transrectal Ultrasound (TRUS) and C-arm X-ray Fluoroscopy (fluoro) data to monitor the seed positions relative to the current target volume during an operation. Towards this goal, an automatic method of assigning seeds to their corresponding insertion needle tracks has been developed to match seeds between modalities so that seed displacements can be computed. This method can be applied to measure intra-operative misplacement, by comparing the desired positions to the actual positions computed from fluoro data, or post-implant movement, comparing the fluoro seed positions to those from post-implant Computed Tomography (CT) data. For the intra-operative and post-implant data, 99.31% and 99.41% of the seeds were correctly assigned, respectively. An average intra-operative seed displacement of 4.94±2.42 mm and a further 2.97±1.81 mm of post-implant movement is measured. This information reveals several directional trends and can be used to preemptively correct the pre-operative plan (pre-plan). en_US
dc.language.iso eng en_US
dc.publisher University of British Columbia en
dc.title Towards intra-operative dosimetry for prostate brachytherapy : improved seed detection and registration to ultrasound using needle detection en_US
dc.type Electronic Thesis or Dissertation en
dc.degree.name Master of Applied Science - MASc en_US
dc.degree.discipline Electrical and Computer Engineering en_US
dc.degree.grantor University of British Columbia en
dc.date.graduation 2012-11 en_US
dc.degree.campus UBCV en_US
dc.description.scholarlevel Graduate en

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