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Mycobacterium tuberculosis Promotes Anti-Apoptotic Activity of the Macrophage by PtpA-Dependent Dephosphorylation of Host GSK3α Poirier, Valérie; Bach, Horacio; Av-Gay, Yossef

Abstract

Mycobacterium tuberculosis tyrosine phosphatase PtpA inhibits two key cellular events in macrophages required for the elimination of invading organisms; phagosome acidification and maturation. Kinome analysis revealed multiple PtpA-dependent changes to the phosphorylation status of macrophage proteins upon M. tuberculosis infection. Among those, we show that PtpA dephosphorylates GSK3α on amino acid Y279, which leads to modulation of GSK3α anti-apoptotic activity, promoting pathogen survival early during infection.

Item Metadata

Title
Mycobacterium tuberculosis Promotes Anti-Apoptotic Activity of the Macrophage by PtpA-Dependent Dephosphorylation of Host GSK3α
Alternate Title
Mycobacterium tuberculosis dephosphorylation of human GSK3α
Creator
Poirier, Valérie; Bach, Horacio; Av-Gay, Yossef
Date Issued
2014-10
Description
Mycobacterium tuberculosis tyrosine phosphatase PtpA inhibits two key cellular events in macrophages required for the elimination of invading organisms; phagosome acidification and maturation. Kinome analysis revealed multiple PtpA-dependent changes to the phosphorylation status of macrophage proteins upon M. tuberculosis infection. Among those, we show that PtpA dephosphorylates GSK3α on amino acid Y279, which leads to modulation of GSK3α anti-apoptotic activity, promoting pathogen survival early during infection.
Subject
Mycobacterium tuberculosis; Macrophage; Tyrosine Phosphatase; Signal Transduction; Apoptosis
Genre
Graduating Project
Type
Text
Language
eng
Series
University of British Columbia. MEDI 649
Date Available
2015-03-11
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivs 2.5 Canada
DOI
10.14288/1.0075838
URI
http://hdl.handle.net/2429/52354
Affiliation
Medicine, Faculty of; Medicine, Department of; Infectious Diseases, Division of
Campus
UBCV
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/2.5/ca/
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Attribution-NonCommercial-NoDerivs 2.5 Canada