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Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability Moosvi, Firas
Abstract
Galbumin, an MR contrast agent is characterized for use in a new class of animal MR experiments. It’s suitability as both a T1 and T2 agent was assessed and it was found that although Galbumin’s relaxivity (4.33 to 5.77 (mM · sec)−1 was comparable to Gd-DTPA, the solution was not available at a high enough concentration to achieve similar T1 weighted effects. Further, it was deemed an unworthy candidate for T2 -weighted imaging as it’s magnetic susceptibility was much too low (2.95 ppm/mM). Finally, we established a theoretical basis for a novel dual contrast agent MR protocol to investigate blood vessel permeability, extracted from previously published work [1] on modelling MR contrast agents. The over-arching goal of this study is to use the live imaging capabilities of MR combined with traditional immunohistochemical techniques to more accurately characterize tumour vessel permeability.
Item Metadata
Title |
Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability
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Creator | |
Date Issued |
2009-05-01
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Description |
Galbumin, an MR contrast agent is characterized for use in a new class of animal MR experiments.
It’s suitability as both a T1 and T2 agent was assessed and it was found that although
Galbumin’s relaxivity (4.33 to 5.77 (mM · sec)−1 was comparable to Gd-DTPA, the solution was
not available at a high enough concentration to achieve similar T1 weighted effects. Further, it
was deemed an unworthy candidate for T2 -weighted imaging as it’s magnetic susceptibility was
much too low (2.95 ppm/mM). Finally, we established a theoretical basis for a novel dual contrast
agent MR protocol to investigate blood vessel permeability, extracted from previously published
work [1] on modelling MR contrast agents. The over-arching goal of this study is to use the live
imaging capabilities of MR combined with traditional immunohistochemical techniques to more
accurately characterize tumour vessel permeability.
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Extent |
7225461 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Series | |
Date Available |
2009-05-01
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0085960
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URI | |
Affiliation | |
Campus | |
Citation |
Moosvi, Firas. 2009. Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability. Undergraduate Honours Thesis. Department of Physics and Astronomy. University of British Columbia.
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Peer Review Status |
Unreviewed
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Scholarly Level |
Undergraduate
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Copyright Holder |
Moosvi, Firas
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International