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A comparison of blood flow of the vastus lateralis during exercise in trained and untrained cyclists as measured by 133 Xenon clearance Sharpe, Glen Patrick
Abstract
The purpose of this investigation was to examine muscle blood flow (MBF) in the vastus lateralis of trained and untrained cyclists using the ¹³³Xenon clearance method. MBF was measured in five trained cyclists (V02max = 68.8 ± 4.2 ml/kg/min) and five untrained subjects (V02max = 48.2 ± 4.2 ml/kg/min) at 150 Watts, the anaerobic threshold (AT), and at 100% V02max. These workloads corresponded to an absolute (150 W), relative (AT) and maximal comparison between groups. ¹³³Xenon dissolved in saline (3-9 MBq in < 0.2 ml volume), was injected in the vastus lateralis muscle prior to ergometer work. Clearance of the isotope was monitored using a gamma camera positioned adjacent to the injection site (Chung et. al., 1987). MBF calculations are based on the half clearance time (T1/2) during the initial steep portion of the clearance curve, and the blood-muscle partition coefficient value of ¹³³Xenon (0.7) according to the formula MBF = (In 2/T1/2) * 0.7 * 100 (Clausen and Lassen, 1971). MBF was not significantly different between the two groups at 150 Watts (28.7 ± 3.7 vs. 27.5 ± 7.9 ml/100g/min for trained and untrained groups respectively) or at AT (35.1 ± 8.6 vs. 29.8 ± 2.6 ml/100g/min), but was significantly higher in the trained group at 100% V02max (35.6 ± 8.1 vs. 27.0 ± 4.3 ml/100g/min). It appears that the high variability in the MBF results may have masked some differences, thereby identifying this limitation in the gamma camera technique. No significant differences were evident across the three exercise conditions in either group, and no significant relationships were detected between MBF and workload (expressed in Watts, ml of oxygen, or % V02max). The lack of a strong correlation between workload and MBF indicates that the technique may not accurately track MBF across all exercise intensities. It appears that the gamma camera technique may not be suitable for measuring MBF at high exercise intensities due to the short time course of ¹³³Xenon washout.
Item Metadata
Title |
A comparison of blood flow of the vastus lateralis during exercise in trained and untrained cyclists as measured by 133 Xenon clearance
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1998
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Description |
The purpose of this investigation was to examine muscle blood flow (MBF) in the vastus
lateralis of trained and untrained cyclists using the ¹³³Xenon clearance method. MBF was
measured in five trained cyclists (V02max = 68.8 ± 4.2 ml/kg/min) and five untrained
subjects (V02max = 48.2 ± 4.2 ml/kg/min) at 150 Watts, the anaerobic threshold (AT),
and at 100% V02max. These workloads corresponded to an absolute (150 W), relative
(AT) and maximal comparison between groups. ¹³³Xenon dissolved in saline (3-9 MBq in
< 0.2 ml volume), was injected in the vastus lateralis muscle prior to ergometer work.
Clearance of the isotope was monitored using a gamma camera positioned adjacent to the
injection site (Chung et. al., 1987). MBF calculations are based on the half clearance time
(T1/2) during the initial steep portion of the clearance curve, and the blood-muscle
partition coefficient value of ¹³³Xenon (0.7) according to the formula MBF = (In 2/T1/2) *
0.7 * 100 (Clausen and Lassen, 1971). MBF was not significantly different between the
two groups at 150 Watts (28.7 ± 3.7 vs. 27.5 ± 7.9 ml/100g/min for trained and untrained
groups respectively) or at AT (35.1 ± 8.6 vs. 29.8 ± 2.6 ml/100g/min), but was
significantly higher in the trained group at 100% V02max (35.6 ± 8.1 vs. 27.0 ± 4.3
ml/100g/min). It appears that the high variability in the MBF results may have masked
some differences, thereby identifying this limitation in the gamma camera technique. No
significant differences were evident across the three exercise conditions in either group,
and no significant relationships were detected between MBF and workload (expressed in
Watts, ml of oxygen, or % V02max). The lack of a strong correlation between workload
and MBF indicates that the technique may not accurately track MBF across all exercise
intensities. It appears that the gamma camera technique may not be suitable for measuring
MBF at high exercise intensities due to the short time course of ¹³³Xenon washout.
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Extent |
2045492 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-05-19
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0077084
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
1998-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.