Go to  Advanced Search

Blood-gas barrier permeability in athletes with exercise-induced hypoxemia

Show full item record

Files in this item

Files Size Format Description   View
ubc_1999-0410.pdf 4.497Mb Adobe Portable Document Format   View/Open
Title: Blood-gas barrier permeability in athletes with exercise-induced hypoxemia
Author: Edwards, Michael R.
Degree: Master of Science - MSc
Program: Human Kinetics
Copyright Date: 1999
Issue Date: 2009-06-16
Series/Report no. UBC Retrospective Theses Digitization Project [http://www.library.ubc.ca/archives/retro_theses/]
Abstract: The effect of incremental exercise to exhaustion on the change in pulmonary clearance rate (k) of aerosolized Technetium 99m diethylenetriaminepenta acetic acid (Tc-99m DTP A), and the relationship between k and the partial pressure of arterial oxygen (PaO₂) during heavy work, was investigated. Eleven male cyclists (age = 2 5 + 2 yrs, height = 181.3 ± 4.0 cm, mass = 80.1 ± 9.5 kg,V0₂max = 5.30 ± 0.37 1/min, mean ± SD) completed a pulmonary clearance test shortly following (39 ± 8 min) a V02max test. Resting pulmonary clearance was completed at least 24 hours before or after the exercise test. Arterial blood was sampled at rest and at one-minute intervals during exercise. Minimum PaO₂ values and maximum A-aDO₂ ranged from 73-92 Torr and 30-55 Torr respectively. No significant difference between resting k and post-exercise k for the total lung (kτ) (0.54 ± 0.19 vs. 0.57 ± 0.17, %/min, p > 0.05) was observed. Pearson-product moment correlation indicated no significant linear relationship between change in kj and minimum PaO₂ (r = -0.26, p > 0.05). These results indicate that averaged over subjects, pulmonary clearance of Tc-99m DTPA following incremental maximal exercise to exhaustion in highly trained male cyclists is unchanged. Lack of a linear relationship between pulmonary clearance rate and minimum PaO₂ during exercise suggests exerciseinduced hypoxemia occurs despite maintenance of alveolar epithelial integrity.
Affiliation: Education, Faculty of
URI: http://hdl.handle.net/2429/9300
Scholarly Level: Graduate

This item appears in the following Collection(s)

Show full item record

UBC Library
1961 East Mall
Vancouver, B.C.
Canada V6T 1Z1
Tel: 604-822-6375
Fax: 604-822-3893